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Inositol Helps Improve Fertility and Reduces Symptoms of Depression

Inositol Helps Improve Fertility and Reduces Symptoms of Depression

Clinical research has demonstrated that inositol improves fertility and can reduce depression. If you know someone who has challenges with fertility or is concerned about depression, share this information about the benefits of inositol with them. Some of the improvements include a decrease in symptoms associated with depression and protection against developing Alzheimer’s Disease. Additionally, clinical studies have provided evidence that this organic nutrient also prevents type 2 diabetes.

Inositol’s reproductive health benefits

According to United States Department of Health and Human Services, approximately five million American women have been diagnosed with polycystic ovarian syndrome (PCOS), which can lead to difficulty in conceiving a child.1 Clinical studies have demonstrated that inositol helps to improve fertility with PCOS. In a double-blind placebo controlled test conducted at the University of Perugia in Italy, 92 women were diagnosed with PCOS, the group that took inositol supplements had a significant improvement in ovarian function.2 Another study from a group working at the University of Rome found that inositol also increased the success of in vitro fertilization.3

Reduce symptoms of depression with inositol

One of the benefits of inositol is that it has the potential to reduce the symptoms of depression as demonstrated in a clinical investigation by a research team from the University of Alberta in Edmonton, Canada. The team found a marked deficiency in inositol levels in the prefrontal cortex of the brain, which is the areas associated with mood regulation, in patients diagnosed with moderate to severe Major Depressive Disorder.4 New research from Harvard Medical School and the University of Toronto suggests that increasing levels of inositol in the brain also serves to protect people from developing Alzheimer’s disease.5,6

Preventing type 2 diabetes with inositol

Numerous studies have demonstrated that inositol increases the body’s sensitivity to insulin. One study conducted at Lyon University in France affirmed that the people who took inositol supplements tolerate glucose much better because of increased sensitivity to insulin. The authors of the study cited their findings as further support of the premise that inositol is useful in the prevention and treatment of type 2 diabetes.7

Dietary sources of inositol

If you want to make sure that you get all the inositol that you need, make sure you eat plenty of grapefruit, beans, and brussel sprouts since these foods are rich in inositol.8 If these foods are not part of your regular menu, make sure to take a multivitamin that contains inositol on a daily basis.



1Department of Health and Humans Services. Polycystic Ovary Syndrome Fact Sheet. Women’s Retrieved from

2Gerli, S., Papaleo, E., Ferrari, A., & Di Renzo, G. Randomized, Double Blind Placebo-Controlled Trial: Effects Of Myo-Inositol on Ovarian Function and Metabolic Factors In Women With PCOS. European Review For Medical And Pharmacological Sciences.(2007)

3Lisi, F., Carfagna, P., Oliva, M., Rago, R., Lisi, R., Poverini, R., & .Moscarini, M. Pretreatment with Myo-Inositol in Non-Polycystic Ovary Syndrome Patients Undergoing Multiple Follicular Stimulation for IVF: A Pilot Study. Reproductive Biology & Endocrinology.(2012)

4Coupland, N.J.; Ogilvie, K.M.; Seres, P.; Hanstock, C; Allen, P.S.Original article: Decreased Prefrontal Myo-Inositol in Major Depressive Disorder. Biological Psychiatry (2005)

5Choi, J., Carreras, I.; Dedeoglu, A. ; Jenkins, B.Detection Of Increased Scyllo-Inositol In Brain With Magnetic Resonance Spectroscopy After Dietary Supplementation In Alzheimer’S Disease Mouse Models.” Neuropharmacology (2010)

6Fenili, D., Brown, M., Rappaport, R., & McLaurin, J. Properties ff Scyllo-Inositol as a Therapeutic Treatment of AD-Like Pathology. Journal of Molecular Medicine. (2007).

7Marine L., C., Roxane E., V., Nicolas J., P., Hédi A., S., Lilas, H., Michel, G., & Christophe O., S. Chronic Treatment with Myo-Inositol Reduces White Adipose Tissue Accretion and Improves Insulin Sensitivity in Female Mice. The Journal of Nutritional Biochemistry. (2012).

8Clement, R.S. and Darnell, B, Myo-Inositol Content of Common Foods: Development Of A High-Myo-Inositol Diet. The American Journal of Clinical Nutrition (1980).

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